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Biological Theory of Depression
The Biological Theory of Depression states that a shortage of serotonin and of noradrenalin located in the synaptic clefts are the basis of depression. Also, it states that unlike being an outcome of a simple decrease in some crucial cerebral transmitter concentrations depression may be the outcome of a disturbed balance between various regulatory systems and consequent transmitter overactivity in some of the brain regions.
A theory of depression that is molecular and cellular says that therapeutic action of antidepressant treatments and stress-induced vulnerability happen via intracellular mechanisms that minorize or maximize, respectively, the neurotrophic factors fundamental for the survival and function of some neurons. Nevertheless, depression is constantly followed by some biological alterations that may thoroughly explain the comorbidity of depression itself and different diseases. Both, the noradrenergic hyperactivity and the corticosteroid overdrive have to do with depression and may impair the ordinary functions of the immune system.
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